Nattokinase
Subtilisin NAT (Bacillus subtilis enzyme)
Preliminary
Nattokinase is a fibrinolytic enzyme extracted from natto, a traditional Japanese food made from fermented soybeans. It has potent activity in breaking down fibrin, the protein matrix of blood clots, and has been studied for supporting healthy circulation and cardiovascular function.
How It Works
Nattokinase functions primarily as a fibrinolytic agent:
- Direct Fibrinolysis: Directly degrades fibrin, the protein that forms the structural framework of blood clots.
- Plasminogen Activation: Enhances the body’s own clot-dissolving system by activating pro-urokinase and tissue plasminogen activator (t-PA).
- Plasmin-like Activity: Exhibits intrinsic plasmin-like proteolytic activity.
- Blood Pressure: May inhibit angiotensin-converting enzyme (ACE), contributing to modest blood pressure reduction.
- Blood Viscosity: May reduce blood viscosity and improve overall circulation.
Natural Food Sources
| Food | Amount per Serving |
|---|---|
| Natto (fermented soybeans) | ~1,000 FU per 50g serving |
Safety Information
Contraindications
- Bleeding disorders – nattokinase can impair clot formation
- Before surgery - stop 2 weeks prior
- Before surgery – stop at least 2 weeks prior
- Active bleeding – do not use
Potential Side Effects
- Easy bruising (uncommon)
- Prolonged bleeding from cuts (uncommon)
- Prolonged bleeding from cuts (rare)
Disclaimer: The information provided is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare provider before starting any supplement regimen.