Scientific Studies

Browse our curated collection of scientific research on natural compounds. Each study includes a plain-language summary and quality rating.

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Systematic Review

Vitamin C and Immune Function: A Review

NutrientsNov 2017
Quality: 5/5
DOI: 10.3390/nu9111211
Systematic Review

Rhodiola rosea for Mental and Physical Fatigue: A Systematic Review

BMC Complementary and Alternative MedicineMay 2012
n=714Quality: 4/5
DOI: 10.1186/1472-6882-12-70
Systematic Review

NAC for Psychiatric Disorders: A Systematic Review

Neuroscience & Biobehavioral ReviewsJan 2015
n=2,000Quality: 4/5
DOI: 10.1016/j.neubiorev.2014.10.023
Meta-Analysis

CoQ10 for Statin-Induced Myopathy: A Meta-Analysis

Mayo Clinic ProceedingsSep 2015
n=575Quality: 4/5
DOI: 10.1016/j.mayocp.2015.05.002
RCT

CoQ10 for Heart Failure: The Q-SYMBIO Study

JACC Heart FailureDec 2014
n=420Quality: 5/5
DOI: 10.1016/j.jacc.2014.08.016
Meta-Analysis

Melatonin for Primary Sleep Disorders: A Meta-Analysis

PLoS ONEMay 2013
n=1,683Quality: 5/5
DOI: 10.1371/journal.pone.0063773
Meta-Analysis

Berberine for Type 2 Diabetes: A Systematic Review and Meta-Analysis

PhytomedicineMar 2021
n=2,569Quality: 4/5
DOI: 10.1016/j.phymed.2020.153433
Meta-Analysis

Zinc Lozenges and Common Cold Duration: A Meta-Analysis

Open Forum Infectious DiseasesApr 2017
n=575Quality: 4/5
DOI: 10.1093/ofid/ofx059
Systematic Review

Probiotics and Anxiety/Depression: A Systematic Review

Journal of Affective DisordersJan 2019
n=1,901Quality: 4/5
DOI: 10.1016/j.jad.2018.09.049
Meta-Analysis

Probiotics for IBS: A Systematic Review and Network Meta-Analysis

The Lancet Gastroenterology & HepatologyOct 2018
n=11,500Quality: 5/5
DOI: 10.1016/S2468-1253(18)30223-2
Meta-Analysis

Curcumin for Depression: A Meta-Analysis of Randomized Controlled Trials

Journal of Affective DisordersOct 2017
n=531Quality: 4/5
DOI: 10.1016/j.jad.2017.06.001
Meta-Analysis

Curcumin for Osteoarthritis: A Systematic Review and Meta-Analysis

BMC Musculoskeletal DisordersJul 2021
n=1,621Quality: 4/5
DOI: 10.1186/s12891-021-04525-2
Systematic Review

Magnesium and Sleep Quality: A Systematic Review

BMC Complementary Medicine and TherapiesSep 2022
n=7,582Quality: 4/5
DOI: 10.1186/s12906-022-03706-z
Meta-Analysis

Magnesium Supplementation for Blood Pressure: A Meta-Analysis

HypertensionAug 2016
n=2,028Quality: 5/5
DOI: 10.1161/HYPERTENSIONAHA.116.07664
RCT

Ashwagandha Effects on Testosterone and Male Reproductive Health

American Journal of Mens HealthDec 2015
n=46Quality: 4/5
DOI: 10.1177/1557988315598713
Meta-Analysis

Omega-3 Fatty Acids for Major Depressive Disorder: A Meta-Analysis

Translational PsychiatryAug 2019
n=2,160Quality: 4/5
DOI: 10.1038/s41398-019-0515-5
RCT

REDUCE-IT: Cardiovascular Risk Reduction with Icosapent Ethyl

New England Journal of MedicineJan 2019
n=8,179Quality: 5/5
DOI: 10.1056/NEJMoa1812792
Meta-Analysis

Vitamin D and Depression: A Systematic Review and Meta-Analysis

Critical Reviews in Food Science and NutritionFeb 2022
n=53,235Quality: 4/5
DOI: 10.1080/10408398.2022.2036099
Meta-Analysis

Vitamin D Supplementation and COVID-19 Outcomes

Scientific ReportsApr 2022
n=76,428Quality: 4/5
DOI: 10.1038/s41598-022-10515-2
Meta-Analysis

Vitamin D and Calcium Supplementation Reduces Cancer Risk

JAMA Network OpenSep 2019
n=30,970Quality: 5/5
DOI: 10.1001/jamanetworkopen.2019.11941
RCT

Lion’s Mane and Cognitive Function in Older Adults

Phytotherapy ResearchMar 2009
n=30Quality: 3/5
DOI: 10.1002/ptr.2634
Meta-Analysis

Omega-3 and Cardiovascular Disease: Meta-Analysis

JAMA CardiologyOct 2019
n=127,477Quality: 5/5
DOI: 10.1001/jamacardio.2019.3780
RCT

Effect of Magnesium Supplementation on Sleep Quality

Journal of Nutritional ScienceOct 2022
n=46Quality: 4/5
DOI: 10.1017/jns.2022.21
Systematic Review

Ashwagandha Root Extract for Stress and Anxiety: A Systematic Review

Journal of Ayurveda and Integrative MedicineJan 2021
n=1,542Quality: 4/5
DOI: 10.1016/j.jaim.2019.01.004

Understanding Our Study Ratings

Each study is rated on methodology quality (1-5 stars). Higher ratings indicate more rigorous research design, larger sample sizes, and more reliable conclusions. Meta-analyses and randomized controlled trials typically receive higher ratings than observational or in-vitro studies.