Vitamin B1
Thiamine
Strong
Vitamin B1 (Thiamine) is a water-soluble vitamin essential for carbohydrate metabolism and energy production. It plays a critical role in nerve function and is vital for preventing beriberi and Wernicke-Korsakoff syndrome.
How It Works
Thiamine functions as a coenzyme in critical metabolic pathways:
- Pyruvate Dehydrogenase: Thiamine pyrophosphate (TPP) is essential for converting pyruvate to acetyl-CoA, linking glycolysis to the citric acid cycle.
- Alpha-ketoglutarate Dehydrogenase: Key enzyme in the citric acid cycle requiring TPP.
- Transketolase: Enzyme in the pentose phosphate pathway, important for nucleotide synthesis and NADPH production.
- Branched-chain Ketoacid Dehydrogenase: Involved in amino acid metabolism.
- Nerve Function: Beyond its coenzyme role, thiamine appears to have direct roles in nerve membrane function and neurotransmitter synthesis.
Natural Food Sources
| Food | Amount per Serving |
|---|---|
| Pork (lean) | 0.8 mg per 3 oz |
| Enriched cereals | 0.5-2 mg per serving |
| Black beans | 0.4 mg per cup |
| Sunflower seeds | 0.4 mg per 1/4 cup |
| Brown rice | 0.2 mg per cup cooked |
Safety Information
Contraindications
- None known - thiamine has an excellent safety profile
Potential Side Effects
- Generally very well tolerated (rare)
- Allergic reactions (rare, usually with IV administration) (rare)
Disclaimer: The information provided is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare provider before starting any supplement regimen.