Ashwagandha Root Extract for Stress and Anxiety: A Systematic Review
Speers AB, Cabey KA, Soumyanath A, Wright KM
Journal of Ayurveda and Integrative Medicine • January 2021
Plain Language Summary
This review confirmed that ashwagandha root extract is effective for reducing stress and anxiety. Studies showed it can lower the stress hormone cortisol by about 23% and significantly reduce anxiety symptoms. Taking 300-600mg of standardized extract (like KSM-66 or Sensoril brands) daily for 6-8 weeks typically produces noticeable benefits. It appears safe for short-term use.
Key Findings
- 1Ashwagandha significantly reduced anxiety scores compared to placebo (SMD = -1.55, 95% CI -2.37 to -0.74)
- 2Cortisol levels were significantly reduced (average 23% decrease)
- 3Effects observed at doses of 300-600mg standardized root extract
- 4Benefits typically seen within 6-8 weeks
- 5KSM-66 and Sensoril extracts showed consistent results
Abstract
This systematic review and meta-analysis examined the efficacy of ashwagandha (Withania somnifera) root extract for managing stress and anxiety. The review included randomized controlled trials using validated anxiety and stress assessment tools.
Study Limitations
- Small number of high-quality RCTs available
- Varying extract preparations across studies
- Short-term studies predominated
- Some studies industry-funded