Berberine for Type 2 Diabetes: A Systematic Review and Meta-Analysis
Liang Y, Xu X, Yin M, Zhang Y, et al
Phytomedicine • March 2021
Plain Language Summary
This analysis of 46 studies found that berberine is effective for lowering blood sugar in people with type 2 diabetes. It reduced HbA1c (a key diabetes marker) by about 0.7%, which is similar to the prescription drug metformin. Berberine also improved cholesterol levels. Taking 500mg 2-3 times daily with meals appears most effective. It can be used alone or combined with diabetes medications for enhanced effect.
Key Findings
- 1Berberine significantly reduced fasting blood glucose (-0.87 mmol/L)
- 2HbA1c reduced by 0.72% on average
- 3Effects comparable to metformin monotherapy
- 4Combination with standard treatments enhanced glycemic control
- 5Also improved lipid profiles (reduced LDL cholesterol)
Abstract
This meta-analysis evaluated the efficacy of berberine for glycemic control in patients with type 2 diabetes. The analysis included 46 randomized controlled trials comparing berberine to placebo or conventional diabetes treatments.
Study Limitations
- Most studies conducted in China
- Variable study quality
- Short-term studies predominated
- Long-term safety data limited