Curcumin for Depression: A Meta-Analysis of Randomized Controlled Trials
Ng QX, Koh SSH, Chan HW, Ho CYX
Journal of Affective Disorders • October 2017
Plain Language Summary
This analysis of clinical trials found that curcumin supplements effectively reduce depression symptoms. Taking 500-1000mg daily was about as effective as antidepressant medications alone, and adding curcumin to antidepressants improved results further. Scientists believe curcumin’s anti-inflammatory properties may explain its mood benefits, since inflammation is linked to depression.
Key Findings
- 1Curcumin significantly reduced depressive symptoms (SMD = -0.34, 95% CI -0.56 to -0.13)
- 2Effects comparable to antidepressant monotherapy
- 3Combination with antidepressants enhanced effects
- 4Doses of 500-1000mg/day curcumin were effective
- 5Anti-inflammatory mechanism may explain antidepressant effect
Abstract
This meta-analysis examined the efficacy of curcumin in reducing depressive symptoms in patients with major depressive disorder or other depressive symptoms. Six randomized controlled trials were included.
Study Limitations
- Limited number of RCTs available
- Small sample sizes in some studies
- Short follow-up periods
- Varying curcumin preparations