N-Acetyl Cysteine (NAC)
N-Acetyl-L-Cysteine
Moderate
NAC is the supplement form of the amino acid cysteine and a precursor to glutathione, the body's master antioxidant. It is used medically for acetaminophen overdose and as a mucolytic. Research shows promise for several mental health conditions, particularly OCD and addiction, as well as for respiratory support.
How It Works
NAC works through multiple pathways:
- Glutathione Synthesis: Provides cysteine, the rate-limiting amino acid for glutathione production.
- Direct Antioxidant: The thiol group directly scavenges free radicals.
- Mucolytic: Breaks disulfide bonds in mucus, making it less viscous and easier to clear.
- Glutamate Modulation: Regulates glutamate via the cystine-glutamate antiporter, relevant for OCD, addiction, and excitotoxicity.
- Heavy Metal Chelation: Binds and helps eliminate certain heavy metals.
- Acetaminophen Overdose: Replenishes glutathione to detoxify the toxic metabolite NAPQI.
Natural Food Sources
| Food | Amount per Serving |
|---|---|
| Not present as NAC in foods | Cysteine found in protein foods |
Safety Information
Contraindications
- Asthma – may cause bronchospasm in some asthmatics
- Active bleeding - NAC has mild antiplatelet effects
Potential Side Effects
- GI upset, nausea (common)
- Sulfur-like odor (body odor, breath) (uncommon)
- Sulfur-like odor (body odor, breath) (uncommon)
Scientific Research
Disclaimer: The information provided is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare provider before starting any supplement regimen.