NAC for Psychiatric Disorders: A Systematic Review
Deepmala D, Slattery J, Kumar N, Delhey L, et al
Neuroscience & Biobehavioral Reviews • January 2015
Plain Language Summary
NAC (N-acetyl cysteine) is an antioxidant amino acid that also affects brain chemistry. This review found it helpful for several mental health conditions, including reducing depression in bipolar disorder, helping with addiction cravings, and improving OCD symptoms when added to standard medications. Taking 2000-3000mg daily in divided doses appears most effective. NAC is thought to work by reducing oxidative stress and balancing glutamate, a key brain chemical.
Key Findings
- 1Significant benefit for depressive symptoms in bipolar disorder
- 2Reduced addictive behaviors (gambling, cannabis, cocaine)
- 3Improved negative symptoms in schizophrenia
- 4Beneficial effects on OCD symptoms as adjunct therapy
- 5Doses of 2000-3000mg daily were most commonly effective
Abstract
This systematic review examined the evidence for N-acetyl cysteine (NAC) in psychiatric disorders. NAC is a precursor to glutathione and modulates glutamate neurotransmission. The review included studies on depression, bipolar disorder, OCD, addiction, and schizophrenia.
Study Limitations
- Heterogeneous study designs
- Some conditions had limited data
- Optimal dosing not established
- Mechanisms not fully understood