Resveratrol
trans-3,5,4'-trihydroxystilbene
Preliminary
Resveratrol is a polyphenol found in red wine, grapes, and certain plants. It gained attention as a possible contributor to the “French Paradox” – lower heart disease rates despite high-fat diets. It has antioxidant and anti-inflammatory properties and may influence longevity pathways and cardiovascular health.
How It Works
Resveratrol works through several pathways:
- Sirtuin Activation: Activates SIRT1 and other sirtuins, NAD⁺-dependent enzymes linked to longevity and metabolic health.
- AMPK Activation: Stimulates AMP-activated protein kinase, a cellular energy sensor, mimicking some effects of caloric restriction.
- Antioxidant Activity: Direct free-radical scavenger and inducer of endogenous antioxidant defenses.
- Anti-inflammatory: Inhibits NF-κB and reduces the production of inflammatory mediators.
- Cardiovascular Effects: Improves endothelial function, reduces LDL oxidation, and has mild antiplatelet effects.
- Mitochondrial Function: May promote mitochondrial biogenesis and improve function in preclinical studies.
Natural Food Sources
| Food | Amount per Serving |
|---|---|
| Red wine | 0.2-2 mg per 5 oz glass |
| Peanuts | 0.01-0.26 mg per 1/2 cup |
| Peanuts | 0.24-1.25 mg per cup |
| Red grapes | 0.01-0.03 mg per cup |
| Berries (e.g., blueberries) | 0.35 mg per 100g |
Safety Information
Contraindications
- Hormone-sensitive cancers – resveratrol has weak estrogenic activity
- Before surgery - may affect bleeding
Potential Side Effects
- GI discomfort at higher doses (uncommon)
- Joint pain (some reports) (rare)
- Joint pain (reported in some trials) (rare)
Disclaimer: The information provided is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare provider before starting any supplement regimen.